Posted: December 30th, 2021
Compose a 500 words assignment on druq design. Needs to be plagiarism free! Drug Design for HIV Background about HIV The human immunodeficiency virus (HIV) was first discovered in 1985.HIV is most commonly transmitted by sexual contact and needle-sharing due to the exchange of body fluids like blood and semen. The virus damages the body’s immune system resulting in AIDS (acquired immune deficiency syndrome). A worldwide epidemic, 39.5 million individuals were infected with HIV/AIDS in 2006. In the same year, 2.9 million deaths were attributed to AIDS (Cichocki, 2008).
HIV is a retrovirus, which store their genetic information as RNA instead of DNA. HIV enters human immune system CD4 cells through specific receptors in its viral coat. Inside the cell, the HIV reverse transcriptase converts the viral RNA into DNA. this DNA is transported into the cell nucleus where it is inserted into the human genome by the HIV integrase enzyme. The HIV DNA may lie dormant, but is later expressed for the synthesis of new HIV proteins and enzymes. The HIV protease is active at this stage of the life cycle where its role is to cut long protein strands to form viral cores.
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